by Perfectus Biomed | 2015 and older, Publications, Tissue Models, Wound Care
Abstract
Mupirocin decolonization of nasal Staphylococcus aureus prior to surgery decreases surgical-site infections; however, treatment requires 5 days, compliance is low, and resistance occurs. In 2010, 3M Company introduced povidone-iodine (PVP-I)-based skin and...
by Perfectus Biomed | 2015 and older, Infectious Disease, Publications
Following a public vote, the 2014 Longitude Prize to develop an idea that will help solve one of the greatest issues of our time will go to a project working on antibiotic resistance. The focus of the £10m award will go to the best idea for a cheap, fast and...
by Perfectus Biomed | 2015 and older, Infectious Disease, Publications
Abstract
VanX is an induced zinc metallo d-Ala-d-Ala dipeptidase involved in the viable remodeling of bacterial cell wall that is essential for the development of VREF. Here we report two cyclic thiohydroxamic acid-based peptide analogs that were designed, synthesized...
by Perfectus Biomed | 2015 and older, Infectious Disease, Publications, Virology
Abstract
Background: Staphylococcus aureus causes serious infections in both hospital and community settings. Attempts have been made to prevent human infection through vaccination against bacterial cell-surface antigens; thus far all have failed. Here we show...
by Perfectus Biomed | 2015 and older, Infectious Disease, Publications, Tissue Models
Abstract
Aims: To develop a semi-high-throughput ex vivo mucosal model for determining efficacy and toxicity of antiseptics.
Methods and results: Explants (5 mm) from freshly excised, porcine vaginal mucosa were infected with methicillin-sensitive Staphylococcus aureus (1...
