Advancements in Tissue Engineering
Tissue engineering has seen remarkable advancements, thanks in part to in vitro models. In vitro 3D reconstructed tissues are created precisely in a controlled, reproducible manner to create layers of cells, biomolecules, and materials to create tissue-specific microenvironments. The models can be created to be normal healthy tissues and also injured or diseased tissues providing a vast array of environments to test products in as tissue models are available for almost all bodily tissues.
Studying Biocompatibility with In Vitro Cell Biology
There is a diverse range of in vitro and ex vivo models, each serving specific purposes in research. NAMSA utilizes these models to develop customized studies that determine and screen leading formulations, product market advantages through comparable competitive assessments, and predict preclinical outcomes through early-stage testing.
Customized Cell Biology Research & GLP Compliance
Our models are customizable, and our scientists can work with you to develop methods specific to your project’s needs. Contact us to learn more about how our highly customizable tissue models can help your research team hit milestones and achieve goals.
Some of the tissue models we offer include:
- Ex vivo Human Skin Model
- Ex vivo Porcine Mucosal Model
- Ex vivo Porcine Burn Wound Model
- In vitro 3D Reconstructed Human Epidermis — Wound Healing/Skin Irritation
- In vitro Human Corneal Epithelium
- In vitro Human intestine model — Toxicity, Healing, and Inflammation
Unlike in vitro models, ex vivo testing can meaningfully predict clinical conditions without the added time and expense of potentially unnecessary in vivo testing.
Regulatory bodies will always require appropriate safety data before approving a product for market release. Having alternatives available helps healthcare practitioners confidently make choices around products that are likely to be effective within clinical settings.
The results from our studies will give you the insight you need to develop and perfect your antimicrobial formulations, implantable devices and wound dressings. In vitro and ex vivo tissue models can both be used to study inflammation and biocompatibility, antimicrobial efficacy and reepithelialization.
Customized studies can support clients much earlier in the product development cycle while supporting non-regulatory goals such as marketing, product superiority claims, IP and grant funding.
- Ex vivo models are a pre-clinical model to predict clinical success
- Ex vivo models reduce the need for live animal studies
- Ex vivo models are a cost-effective way of screening multiple formulations to identify best lead products