by Perfectus Biomed | 2015 and older, Publications, Virology
Abstract
While there has been great progress in treating HIV-1 infection, preventing transmission has thus far proven an elusive goal. Indeed, recent trials of a candidate vaccine and microbicide have been disappointing, both for want of efficacy and concerns about...
by Perfectus Biomed | 2015 and older, Publications
Abstract
Staphylococcus aureus and Streptococcus pyogenes colonize mucosal surfaces of the human body to cause disease. A group of virulence factors known as superantigens are produced by both of these organisms, which allows them to cause serious diseases from the...
by Perfectus Biomed | 2015 and older, Publications
Abstract
Superantigens interact with T lymphocytes and macrophages to cause T lymphocyte proliferation and overwhelming cytokine production, which lead to toxic shock syndrome. Staphylococcus aureus superantigen toxic shock syndrome toxin-1 is a major cause of menstrual...
by Perfectus Biomed | 2015 and older, Publications, Virology
Abstract
Glycerol monolaurate (GML) is a fatty acid monoester that inhibits growth and exotoxin production of vaginal pathogens and cytokine production by vaginal epithelial cells. Because of these activities, and because of the importance of cytokine-mediated immune...
by jennieritchie | 2015 and older, Publications
Abstract
Prior studies suggest Staphylococcus aureus exotoxins are not produced when the organism is cultured in human blood. Human blood was fractionated into plasma and water-lysed red blood cells and demonstrated that mixtures of α and β globins of hemoglobin (as low...
by Perfectus Biomed | 2015 and older, Personal Care, Publications
Abstract
We determined vaginal Staphylococcus aureus superantigens. Staphylococci were quantified from tampons/diaphragms in 2003 to 2005, with counts compared to those determined in 1980 and 1981. In 2003 to 2005, more women were colonized than in 1980 and 1981 (23...
