by Perfectus Biomed | 2015 and older, Infectious Disease, Publications, Tissue Models
Abstract
Aims: To develop a semi-high-throughput ex vivo mucosal model for determining efficacy and toxicity of antiseptics.
Methods and results: Explants (5 mm) from freshly excised, porcine vaginal mucosa were infected with methicillin-sensitive Staphylococcus aureus (1...
by Perfectus Biomed | 2015 and older, Biofilm, Publications, Tissue Models
Abstract
Biofilms are a sessile colony of bacteria which adhere to and persist on surfaces. The ability of bacteria to form biofilms is considered a virulence factor, and in fact is central to the pathogenesis of some organisms. Biofilms are inherently resistant to...
by Perfectus Biomed | 2015 and older, Publications, Tissue Models
Abstract
Staphylococcal superantigens (SAgs), such as toxic shock syndrome toxin-1 (TSST-1), are the main cause of toxic shock syndrome (TSS). SAgs deregulate the host immune system after penetrating epithelial barriers such as the vaginal mucosa. In response to TSST-1,...
by Perfectus Biomed | 2015 and older, Publications, Tissue Models
Abstract
Background: Chlorhexidine gluconate (CHG) and povidone iodine (PI) are rarely used concurrently despite a lack of evidence regarding functional incompatibility of these agents.
Methods: CHG and PI, alone and combined, were evaluated against Staphylococcus...
by Perfectus Biomed | 2015 and older, Publications, Tissue Models
We investigated the effects of glycerol monolaurate (GML) on Lactobacillus, Candida, and Gardnerella vaginalis human vaginal microflora. Our previous work demonstrated that 6 months of GML treatment vaginally does not alter lactobacillus counts in...
by Perfectus Biomed | 2015 and older, Publications, Tissue Models
Abstract
An in vitro pharmacodynamic investigation was conducted to explore whether the area under the concentration time curve from 0 to 24 h (AUC0–24)/MIC ratio could predict fluoroquinolone performance against Bacteroides fragilis. An in vitro model was used to...
