by Perfectus Biomed | 2015 and older, Publications
Abstract
Objectives: To identify whether mutations in gyrA and gyrB confer fluoroquinolone resistance in Bacteroides fragilis.
Methods: Eight fluoroquinolone-resistant (FQR) strains were complemented with plasmid-mediated B....
by Perfectus Biomed | 2015 and older, Publications, Tissue Models
Abstract
An in vitro pharmacodynamic investigation was conducted to explore whether the area under the concentration time curve from 0 to 24 h (AUC0–24)/MIC ratio could predict fluoroquinolone performance against Bacteroides fragilis. An in vitro model was used to...
by jennieritchie | 2015 and older, Publications
Abstract
Pharmacodynamics provides a rational basis for optimizing dosing regimens by describing the relationship between drug, host and antimicrobial effect. The successful identification of meaningful pharmacodynamic outcome parameters can, therefore, greatly...
by Perfectus Biomed | 2015 and older, Publications
Abstract
In vitro pharmacodynamic studies investigating the antimicrobial properties of five fluoroquinolones, (trovafloxacin, sparfloxacin, clinafloxacin, levofloxacin, and ciprofloxacin) against Bacteroides fragilis ATCC 23745 were conducted. The times required to...
by Perfectus Biomed | 2015 and older, Infectious Disease, Publications
Evaluation of the health care system has identified the need for more efficient and productive use of resources for providing quality patient outcomes. The use of critical pathways has been well described in the nursing literature. The primary goal is to combine...
