by jennieritchie | 2015 and older, Publications
Abstract
Exotoxins of Staphylococcus aureus belong to a family of bacterial proteins that act as superantigens by activating a large subset of the T-cell population, causing massive release of inflammatory cytokines. This cascade can ultimately result in toxic...
by jennieritchie | 2015 and older, Publications
Abstract
Many exotoxins of gram positive bacteria, such as superantigens (staphylococcal enterotoxins, toxic shock syndrome toxin-1 [TSST-1], and streptococcal pyrogenic exotoxins) and anthrax toxin are bioterrorism agents that cause diseases by immunostimulation...
by Perfectus Biomed | 2015 and older, Publications
Abstract
Despite knowledge of the effects of toxic shock syndrome (TSS) toxin 1 (TSST-1) on the adaptive immune system, little is known about stimulation of the innate immune system, particularly epithelial cells. This study investigated the interactions of...
by Perfectus Biomed | 2015 and older, Publications
Abstract
Background: Purpura fulminans is an acute illness commonly associated with meningococcemia or invasive streptococcal disease, and it is typically characterized by disseminated intravascular coagulation (DIC) and purpuric skin lesions. In this article, we report...
by Perfectus Biomed | 2015 and older, Publications
Toxic shock syndrome (TSS) is an acute-onset, multisystem illness characterized by fever (>102°F), hypotension (systolic pressure, <90 mm of Hg), sunburn-like rash, peeling of the skin, and a variable multiorgan component that often initially appears flu-like,...
by jennieritchie | 2015 and older, Publications
Abstract
Twelve laboratory mutants and 32 ciprofloxacin-resistant isolates of Bacteroides fragilis were examined for the mechanism(s) of fluoroquinolone resistance. Five mutants had mutations in gyrA. One mutant and two clinical isolates contained a mutation...
