Porcine skin serves as a proven model translatable to human skin.
We use portions of skin from pigs destined for human consumption either large pieces of whole skin or explants to test your experimental therapeutics in a cost-effective manner.
- Porcine skin arrives at our facility 1-4 hours after slaughter from pigs raised for human consumption. We experiment on the prepared skin in large sections or as small biopsies grown in transwells. Therapeutics under investigation are applied to the skin before or after the biopsies have been harvested. We measure the effects of your products on either the natural flora of the pig or a known human pathogen seeded onto the skin.
- Explants are used to test the cellular toxicity and antimicrobial properties of your products.
- We also simulate a wound in the skin by means of incision or removal of part of the epidermis and dermis
Relevant Therapeutic Areas
Porcine skin serves as a relevant model for wound care. The skin has comparable thickness, hair follicle density, and wound closure via reepithelialization.
We use our porcine skin model to study inflammation by testing the tissue for known biomarkers associated with inflammatory processes. We can apply experimental formulations onto large or small areas of skin and then harvest uniformly sized explants with a biopsy punch. These explants are analyzed for inflammatory cytokine production.
Porcine skin testing is commonly used to test formulations or compounds that are applied to the skin (e.g., presurgical products). We can track efficacy against host flora or seed the skin with known pathogens and track how they respond to the compound. We can apply this testing to large or small areas of skin.
How can Perfectus Biomed advance your project?
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We are happy to help with your microbiological requirements and with any other queries you may have.