Perfectus Biomed support the biological evaluation of your product. In addition to our UKAS accredited biofilm and anti-infective assays, we also support your R&D and regulatory claims via cell biology, virology and molecular biology. The cell services department at Perfectus Biomed have been delivering a quality client service for many years now, and we are extremely proud of, and excited by, how our cell service offering has grown, particularly over the past 12 months.

We typically offer cell services to support our clients for one of three reasons:

  1. Research and Development – product development, screening and pre-clinical data.
  2. Biocompatibility and Safety/Regulatory Requirements – legal requirements and label claims.
  3. Marketing – evidence to support the product on the market by highlighting competitive advantages, differentiations and USPs.

What we can offer

We use in vitro wound models and cell models to aid biocompatibility assessments, measuring parameters such as cytotoxicity, hemocompatibility, irritation, corrosion, wound healing rates and proliferation viability. Testing can also be carried out to GLP.  Below are examples of some of the methods we can provide to support your product, depending on your requirements.

Biocompatibility and Safety Testing

  • In vitro cytotoxicity: BS EN ISO 10993-5
  • In vitro skin irritation using 3D reconstructed human epidermis: OECD Test No. 439
  • In vitro skin corrosion using 3D reconstructed human epidermis: OECD Test Guideline 431

Regulatory and Label Claims

  • In vitro virucidal activity: BS EN 14476
  • Macrophage activation assay (for use in diabetes care and inflammatory responses)
  • Regulation of inflammatory cytokines
  • In vitro colonised skin model
  • In vitro anti-parasitic assessment

Marketing and Research & Development

  • In vitro scratch wound model
  • In vitro 3-dimensional wound models
  • Bacterial attachment to mammalian cells
  • In vitro gut microbiome models

Molecular Services:

  • qPCR assessment of mixed species biofilm and planktonic populations
  • Regulation of biofilm forming genes in response to test products
  • Screening samples for the presence of pathogenic viruses and bacteria
  • Molecular analysis – pathway targeting
  • Other – please ask

A full list of cell services that we can provide can be found below:

  • Anti-viral fogging
  • Skin irritation
  • Skin corrosion
  • In vitro cytotoxicity
  • Co-culture with monolayer
  • Co-culture with 3D skin
  • Standard anti-viral testing
  • Cell proliferation/viability
  • Collagen production
  • Scratch wound closure
  • Macrophage activation
  • Wound closure in 3D skin
  • MMP concentration assessments
  • Biofilm-wound models
  • Wound closure in 3D skin
  • Acne models
  • Phenotypic screening of drugs
  • Basic gut epithelial models
  • Cancer invasion assays
  • Corneal model (bacterial adhesion, eye irritation)
  • Oral models (oral care, bacterial adhesion)
  • Vaginal models (feminine hygiene care/bacterial adhesion)
  • Diabetic models

To see a full list of the human and animal cell types we currently have available, please visit our website.

New Services

Perfectus Biomed continually work towards growing our services in order to provide a more comprehensive testing package to new and existing clients. For our cell services, we can now offer:

  • Molecular analysis – pathway targeting
  • Genotoxicity
  • Histological analysis
  • Complex gut microbiome models
  • Parasite invasion models

If you would like further information on any of the above or if you would like to discuss in detail how we can support your work, please get in touch and we would be happy to arrange a call or prepare a work plan for you. We would also be happy to arrange an on-site visit if you would like to come and see our facilities and discuss your work in further detail with our team.

Get in Touch